Our Endometriosis supplement ingredients, deep dive.

Endometriosis is an unpleasant condition where cells from the endometrium (womb lining) find themselves in other places in the body. This causes a problem at the time of menstruation as these endometrial cells shed blood in inappropriate places. This can cause sacks and cysts, inflammation and pain. There are a number of mechanisms involved in Endometriosis, and for a resolution of symptoms, a few points need to be addressed – the normalization of oestrogen, supporting the body’s immune system to identify and destroy endometrial cells that are in the wrong place and to prevent the growth of the endometrial cells that are in the wrong place. Although mainstream treatment can be difficult and invasive, there are a few natural substances that can help.

Endo Complete Support is a nutritional targeted support with 12 powerful ingredients to target the multiple symptoms and triggers of Endometriosis. We wanted this supplement to be as easy for you as possible. Supporting the many systems in the body that are affected by the condition, we took a multifactorial approach to the formula to give you the most comprehensive product. Combining symptom fighting ingredients into one easy to take formulation gives you everything you need to support your diet and your body. 

Here’s a deeper dive into the ingredients :

Broccoli – (sulforaphane) 

Broccoli contains a substance called sulforaphane which is a sulfur rich compound necessary for liver function and oestrogen detoxification, a critical step in normalizing oestrogen levels in women with endometriosis. Oestrogen levels tend to be high in women with endometriosis, the consumption of sulforaphane and its effects may be beneficial. Studies confirm the anti-inflammatory effect of sulforaphane and its beneficial suppressing effect on the endometrial tissue growth outside the uterus in women with Endometriosis. Broccoli also contains a substance called glucosinolates which converts into another substance in the body called isothiocyanates which are equally important to those with endometriosis. Both glucosinolates and isothiocyanates have an anti-inflammatory effect once in the body once metabolised which may contribute towards a reduction in endometrial symptoms. These substances may also promote normalisation of the immune system. Your immune system needs to be able to recognise endometrial cells that are in the wrong part of the body to destroy them. Normalising immune function with substances such as those found in broccoli can further support the symptoms of endometriosis. 

Interestingly, broccoli is the only member of the cruciferous vegetable family that is not associated with an increased risk of endometriosis. So not only does it provide benefits to women with endometriosis, broccoli is the only source of sulforaphane that should be consumed concentrated in supplemental form for women with endometriosis. At Yoppie, we search through the research to provide only the exact ingredients that will benefit women with endometriosis. 

Indole-3-carbinol 

Indole-3-carbonol (I3C) is a natural compound and another derivative of broccoli useful to women with endometriosis. After ingestion, the body converts it into another substance called diindolylmethane (DIM). This conversion happens upon digestion. There is some research that suggests that DIM regulates the balance of oestrogen in the body, making it useful for those with altered oestrogen metabolism. Indole-3-carbonol works with the liver to balance oestrogen and to detox old oestrogen and to prevent it from converting into its more potent and toxic form. Indole-3-carbonale has been heavily researched into its role in endometriosis and oestrogen metabolism. 

Vitamin D3 

Vitamin D contributes towards normal inflammatory responses in your body. This normalisation of inflammatory responses is beneficial to individuals with endometriosis. Inflammation is a major cause of pain associated with Endometriosis. Research suggests that vitamin D3 supplementation has a positive effect on those with Endometriosis and it reduces the number of stromal cells (the cells involved in endometrial tissue growth). 

Vitamin E 

Vitamin E is a fat-soluble vitamin that helps to protect your cells from oxidative damage. Protecting the cells from oxidation is important in women with endometriosis as they typically have a high level of inflammation which leads to oxidation. Research shows that vitamin E supplementation reduces pelvic pain and dysmenorrhea (very painful periods) in women with Endometriosis. 

Vitamin B6 

Vitamin B6 is needed for the balance of hormones in the body. It is needed for a process in the liver that converts oestrogen into a less harmful form, giving it a weaker action in the body, therefore supporting women with endometriosis. 

Vitamin B12

Vitamin B12 is another nutrient that may be useful to women with endometriosis. Vitamin B12 contributes towards normal homocysteine levels (a blood marker) which can contribute towards the development of endometriosis. 

Magnesium 

Magnesium is a mineral that is often not consumed in adequate amounts. It contributes towards normal muscle and nerve function. The communication between the muscles and nerves is an important factor in menstrual related pain, and magnesium supplementation has been shown to decrease pain at the time of menstruation. 

Turmeric 

Turmeric contains the active compound curcumin which has been shown in many research papers to have an anti-inflammatory effect. This decrease in inflammation is especially beneficial to those with dysmenorrhea, and studies show turmeric to be effective against both the severity and duration of menstrual pain in women with dysmenorrhea.  

Milk thistle 

Milk thistle is an herb most famous for its action and support of the liver. A properly functioning liver is needed to convert excess oestrogen into its less toxic and weaker form benefiting those with endometriosis. 

N-acetyl L-cysteine (NAC)

N-acetyl L-cysteine is an amino acid based nutrient that works on several pathways in the body. One of these pathways is the formation of an antioxidant called glutathione. This is made in the body with the help of N-acetyl L-cysteine and reduces inflammation. Studies show that N-acetyl L-cysteine reduces the formation and size of ovarian endometrial cysts. 

Calcium D Glucarate

Calcium D glucarate is a nutrient that supports the liver's detoxification of oestrogen. These reduced oestrogen levels are beneficial to women with endometriosis. 

Lactobacillus Acidophilus

Lactobacillus acidophilus is a beneficial bacteria belonging to the lactobacillus family. Beneficial bacteria is needed in the gut in adequate amounts for the proper functioning of the body. Lactobacillus bacteria produce substances in the gut which help to control inflammation. Studies suggest that lactobacillus strains, including acidophilus can reduce the severity of pain in women with Endometriosis. 

To find out more about Yoppie’s condition supplements for PCOS & Endometriosis you can go here. Still got questions? Read our FAQs or ask our experts here.